The "Enable full Wave support for legacy (MME) software (Less efficient)" box must be checked when running recording/sequencing software that is not optimized to support WDM with a MOTU audio interface. As of this writing, only Cakewalk's Sonar supports WDM. This box has no affect on ASIO applications. Be aware when not checked that outputs will not be seen as channelized pairs when viewed in the Windows multimedia Control Panel, yet they will appear independently in applications such as Sonar.