Yes...
Emagic has created a Virtual Sample Memory Manager and it is available for free download at the emagic.de The VSM Manager Extension adds virtual memory management to the EXS24. The VSM Manager utilizes an intelligent algorithm that keeps "most recently used data" in RAM and sources out "data that is not used anymore" to hard disk. Using this technology, the EXS24 can play back samples of practically any size. Install VSM Manager into System:Extensions.