The following settings should be applied: Control Panels-->multimedia-->audio tab-->set the preferred device for recording and playback to the Digidesign Audiomedia III: Ch 1-2.Control Panels-->multimedia-->devices tab-->audio devices-->check that "Audio for Digidesign Multimedia Devices" is the only device listed.Control Panels-->sounds-->set the Schemes to "No Sounds".My Computer's-->Properties-->Device Manager-->Disk drives properties settings have the DMA enabled.My Computer's-->Properties-->Device Manager-->other devices (if present) need to be disabled in this hardware profile. My Computer's-->Properties-->Device Manager-->Sound, Video and Game Controllers needs to list the Digidesign Audiomedia III card. Additional drivers in this window may cause conflicts within Pro Tools