Yes, the Analog inputs are balanced (XLR / 1/4" TRS combo connectors). The gain of the analog inputs are continuously variable so there is no reference calibration level. By choosing Mic, Instrument, or Line it can drive the A/D converter to full scale with any signal from -45dBu to a maximum input of +24dBu. Performance is optimized for either Mic level or -10dBV line level inputs.