These issues are often common at first. There are a few settings to adjust to smooth out the audio performance. Please note, if your system does not meet the system requirements of your chosen DAW software, these issues may not resolve.

Right click on your PreSonus interface icon in your system tray just to the left of the time. Set the CPU setting to HIGH. If HIGH setting does not improve performance, try LOW.
Right click on your My Computer icon and select Properties.

Click the Advanced tab, click the Settings button under Performance, click Advanced tab, then set to Background Services under Processor Scheduling.

Click Start menu, Control Panel and double click into Network Connections. If you have a Wireless Network Connection, right click and 'disable' this while you are running your PreSonus interface.

If you are using Cubase LE, click Devices menu, select Device Setup, and select VST MULTITRACK. Set the number of disk buffers to 12; set disk buffer size to 128 or 256; and click "APPLY".

Make sure you are set to the Presonus ASIO driver. Then click the 'Expert' button and set "audio priority" to VERY HIGH and uncheck "multi processing" if applicable. You may also want to increase any related settings within other recording software.

Lastly, right click on My Computer icon, select Properties, click Hardware tab, and then click the