Absolutely. You will find there is a 256 output on the back of the Sync DA that connects right into the 888/24 clock input. If you need more 256 outputs, you may change an internal jumper in the Sync DA to change one of the Word Clock outputs to another 256 output. This configuration would give 4 word clock outputs and 2 Digidesign 256 outputs. Perfect for a 16 track Pro Tools session.