Cubase and Nuendo are also used by many GPO users and many have made large orchestrations using these sequencers. Cubase and Nuendo are very reliable and also gives some of the best performance.

•Mod Wheel Volume resets to "0" problem when you hit stop
Since ModWheel controls volume, users can't hear their music when they hit play again.
SOLUTION: The setting that should fix the CC1 reset problem in Cubase SX is in File/Preferences. The MIDI section has two checkboxes, named "Reset on Part End" and "Reset on Stop". If these are UNCHECKED, GPO users should have no problems with CC1 resetting to 0.

(from garritan.com)