"This plug-in only processes 48 channels at a time. The current selection...

"This plug-in only processes 48 channels at a time. The current selection is not a multiple of that amount" in Pro Tools 5.3.1.

This message may appear on Pro Tools 5.3.1 while attempting to use any Audiosuite plug-ins. Throwing away the Pro Tools Preference file should resolve the issue.

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