The ability to re-establish a connection with a 3rd party device driver after waking from sleep or hibernation mode is system dependent. Because of this, M-Audio recommends setting your computer to never go to sleep. Instead, it is recommended that you turn off your monitor, or completely power off the computer. If your M-Audio device is not working after waking from sleep mode, restart your computer to re-establish a connection with the device.

If you would like to use sleep mode, power off your M-Audio ProFire610 before putting the computer in sleep mode, and wake the computer from sleep mode before powering your device back on. Caution: Do Not Hot-Plug FireWire Devices